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Medication adherence among patients with chronic diseases averages only 50% in developed countries according to the World Health Organization (WHO). Non-adherence has significant ramifications, both clinically and economically. For patients, it can result in poor health, requiring additional hospitalizations and medical visits. It reduces productivity and compromises quality of life, possibly ending in death. It also significantly burdens healthcare systems, with estimates of avoidable costs ranging up to US$290 billion in the US and €1.25 billion in Europe. You can read more about this in the blog post "Drug delivery devices: How everyone wins when patient compliance is achieved".
Implantable or wearable drug delivery devices such as insulin pumps, used in the treatment of diabetes, could make a major contribution to the improvement of medication adherence. The current trend for these devices is to become less invasive, with smaller dimensions and parts miniaturised to precise tolerances. This results in reduced weight and greater ease of use. When complex electronic components must be embedded, they too are designed to be compact, with a wall thickness that is as thin as possible.
The main objectives in developing a new device include:
Investigation into high performing materials can help to address these needs, as can partnering with an experienced material-solutions provider as early as possible during the design phase. Take a look at our blog post "3 key factors to consider for material selection in drug delivery devices" for more on this.
After the first high-performing implantable PEEK (Polyetheretherketone) was introduced by Invibio in 1999, the company continued to pioneer novel materials, and PEEK gained more and more acceptance in the medical market.
The medical industry has successfully utilised this unique polymer for long-term implantable devices – for spine, trauma, orthopedics, extremities, cranio-maxillofacial and dental applications. Invibio’s medical-grade PEEK-OPTIMA™ polymer is a reliable implantable material with 500+ medical devices FDA cleared in the US alone, and 13 million devices implanted worldwide:
There are many underlying reasons for the successful use of PEEK in medical devices. The thermoplastic polymer is biocompatible, which is an absolute requirement for implantable applications. Also, PEEK is inherently radiolucent, so medical imaging by X-ray, CT scan and MRI, are artefact-free and therefore facilitate monitoring and diagnosis with unobstructed views. It can be sterilised using standard processes such as gamma and e-beam radiation and steam sterilisation.
Evolving minimally invasive surgical techniques require continual advancement in catheter and intrathecal systems — whether developing a catheter to be used acutely in the delivery of a specialized device or a drug delivery system that will be implanted long-term:
Are you about to design the next generation implantable, connected e-drug delivery device or interested in medical devices in general?
Marcus Jarman-Smith, Strategic Marketing and Business Development Manager at Victrex
Marcus joined Victrex in 2006 and has held technical roles with Victrex's medical business unit (Invibio) and commercial roles, most recently in Business Development, scouting for breakthrough technologies as well as supporting the development of Victrex's Additive Manufacturing offering. Marcus holds a PhD in chemical engineering, tissue engineering and biomaterials from the University of Bath, in the UK. Marcus's expertise is in PEEK in medical and dental applications as well as food contact, materials and technologies for Additive Manufacturing and 3D printing.
From the invention of PEEK over 40 years ago, Victrex has continually pioneered new PAEK-based polymers, materials and solutions that have transformed markets, delivering global impact in the toughest environments.
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